Studies on Nitrofuran Derivatives. VIII. Synthesis of 3-(5-Nitro-2-furyl) isoxazoles.
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چکیده
منابع مشابه
Statistical analysis on toxicity of a nitrofuran derivative, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.
A food additive, furylfuramide or AF-2, which had been used in Japan since 1965 and structurally is composed of 5-nitro-2-furyl radical and acrylamide, was re-examined mainly on chronic toxicity by statistically reviewing published data. The conclusions are as follows: 1) The maximum safety dosage which shows no demonstrable change in rats must be corrected at least to 1/170 of the value which ...
متن کاملRelationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive.
of the 27 nitrofuran derivatives tested had mutagenic effects on E. coli, but none of them had mutagenic effects on S. typhimurium. Twenty-five compounds had DNA-modifying effects on E. coli, and 24 compounds had effects on the DNA of S. typhimurium. Fifteen of the 27 compounds are known to be carcinogenic. Fourteen of these 15 carcinogenic derivatives had mutagenic effects on E. coli and DNA-m...
متن کاملFuran derivatives. ЬХХП. Synthesis and some properties of l-(5-nitro-2-furyl)- -2- (5-aryl-2-furyl)ethylenes
Wittig reaction has recently been applied also in the preparation of 5-nitrofuran derivatives of ethylene [1—5]. The quoted syntheses were accomplished starting either from 5-nitrofurfuryl halides which were converted into 5-nitrofurfurylidenephosphoranes and subsequent condensation of the latter with carbonyl compounds [1—4], or the intermediate phosphoranes were prepared from other furfuryl h...
متن کاملNitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl-2-isoxazolines.
متن کاملSynthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives.
Twelve 1-phenyl-, 1-thiocarbamoyl- and 1-N-substituted thiocarbamoyl-3-(2-furyl)-5-phenyl/(2-furyl)-2-pyrazoline derivatives were synthesized. The chemical structures of the compounds were proved by IR, (1)H NMR, Mass spectrometric data and microanalyses. The antidepressant activities of the compounds were investigated by Porsolt's behavioural despair (forced swimming) test on albino mice. 1-N-...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1967
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.15.1806